quercetin for covid long haulers

As a result, Valeria Mondelli, an immunologist at Kings College London, is advocating trials of anti-inflammatory medications for long Covid patients. [xv] Naviaux RK. A lot of caregivers have taken over all of the household chores, Erlanson says. She suggests that friends and extended family bring meals or provide respite so the primary caregiver can leave the house for a short time. The information in this article is current as of the date listed, which means newer information may be available when you read this. Janus kinase (JAK)-inhibitors and coronavirus disease 2019 (Covid-19) outcomes: a systematic review and meta-analysis. 2021 Dec;5:11-18. doi: 10.1016/j.jdin.2021.07.006. About 54% of hospitalized patients had long-hauler symptoms; about 34% of non-hospitalized patients had symptoms. [xx] Rao TP, Ozeki M, Juneja LR. Join one million Future fans by liking us onFacebook, or follow us onTwitterorInstagram. Epub 2021 Aug 3. The most common symptom, which Heightman says was experienced by more than 80% of patients in her clinic, is a deadening fatigue which impairs their life, making it difficult to complete the simplest of daily tasks. Erlanson did not know whether she received the drug or a placebo until the study was unblinded, at which time she received confirmation that she did receive the drug. The site is secure. A recent study in the U.K. found that post-COVID fatigue and sleep disturbances didnt have much relation to depression, anxiety, PTSD or other psychiatric conditions, either preexisting or resulting from having the virus. 8600 Rockville Pike eCollection 2020 Sep. Grundeis F, Ansems K, Dahms K, Thieme V, Metzendorf MI, Skoetz N, Benstoem C, Mikolajewska A, Griesel M, Fichtner F, Stegemann M. Cochrane Database Syst Rev. Patterson predicts that the consequences of long COVID will place a huge burden on the healthcare system. PMID: 34368790; PMCID: PMC8328568. Health Authorities Call For More Research on Long COVID. [xxvii] Scherer PE, Kirwan JP, Rosen CJ. People with long COVID may refer to themselves as long haulers. The investigators hypothesize that quercetin, as a strong scavenger and anti-inflammatory agent, can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19. Android, The best in medicine, delivered to your mailbox. Insomnia and other sleep disturbances are common in post-COVID patients, leading to persistent fatigue and daytime sleepiness. Heightman adds many long Covid patients also simply get better over the course of time, as their body recovers and heals. Privacy Policy. SN Compr Clin Med. Clipboard, Search History, and several other advanced features are temporarily unavailable. While governments have been scrambling to dedicate funding to further our understanding of the disease in February, the National Institute for Health Research and UK Research and Innovation awarded scientists at the University of Birmingham 2.2 million to study long Covid clinical trials examining different treatment possibilities are still yet to get underway. Patterson stresses that even though the relative mortality of COVID-19 may seem low, the potential short-term and long-term effects can still be devastating. But while more research is likely to be needed before medications like prebiotics or anti-inflammatories are recommended for long Covid patients as part of general clinical practice, some individual symptoms are already proving more treatable than others. Prolonged symptoms occur because of abnormal response from the immune system, explains Bruce Patterson, MD, a leading virologist, researcher in long-haul COVID-19 infections, and CEO of IncellDx, a cutting-edge medical diagnostics company. Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it's official. Ordinarily, about 90% of scalp hair follicles are in the growing stage (anagen). I recommend avoiding GPS (gluten, processed foods and sugar) and DNA (drugs, nicotine, alcohol). [xix] In other words, in many cases, sleep disturbances have a physiological, not psychological, basis and may respond well to supplements that support sleep. SARS-CoV-2 infection is linked to diabetes risk. Instead, remnants of the viruses' genetic material hide in reservoirs where they induce local inflammation. According to the Centers for Disease Control and Prevention (CDC), 1 in 13 adults in the U.S. (7.5%) become COVID "long-haulers," or people whose COVID-19 symptoms last three or more months after they've been infected. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Their exercise intolerance affects their mental health status. Epub 2021 Jul 15. Published online January. Lancet Diabetes Endocrinol. Existing Drugs May Be Capable of Helping COVID Long-Haulers Recover. Review the reports and resolutions submitted for consideration at the 2023 Annual Meeting of the AMA House of Delegates. A handpicked selection of stories from BBC Future, Culture, Worklife, and Travel, delivered to your inbox every Friday. The ACA Sports Council named him Sports Chiropractor of the Year in 2015. I began mixing up some of my words, and I was getting hot flashes. The CDC defines long-haulers syndrome also known as PASC (post-acute sequelae of SARS-CoV-2) or long COVID as a wide range of new, returning or ongoing health problems people experience after first being infected with the SARS-CoV-2 virus. For more information, please see our Lack of concentration. For those who continue to struggle, however, the hope is that the millions of dollars of research grants being handed out will yield some viable treatment possibilities, otherwise long Covid may leave indelible social and economic consequences on society. Detailed Description: When Melissa Heightman set up the UK's first post-Covid-19 clinic at University College London Hospitals (UCLH) in May 2020, she expected that the bulk of her time would be filled helping patients recover from the after-effects of spending many weeks on a ventilator. CytoDyn, the company that manufactures leronlimab, said in a press release that their Phase 2 clinical trial showed a significant improvement in 18 of 24 long COVID symptoms studied in the non-placebo group. Visit our online community or participate in medical education webinars. In addition to emphasizing sources of quercetin in their diet, Boham says, long-COVID patients can supplement with 500 mg twice a day. In the meantime, CytoDyn is conducting two Phase 3 trials of leronlimab in Brazil. In particular, Ebola has already taught scientists a lot about the capacity of viruses to linger in the body, for months and sometimes even years. Recent epidemics have provided one way of gaining crucial clues about what these underlying causes might be. It isn't clear how long these effects might last. Learn more. 2 Not a lot is known about COVID long-haulers at the moment. PMID: 34783824; PMCID: PMC8596199. 2021;11(5):e047680. 6 7. One of the major challenges for doctors attempting to treat long Covid is that there are likely to be a variety of underlying triggers or causes, depending on the patient. The man spread the virus by infecting a sexual partner, after it had lain dormant in his testes for at least five years. COVID-19; SARS-CoV-2; flavonol; quercetin. This chemical compound ( flavonoid ) is naturally found in foods including apples, onions, teas, berries, red wine, and herbs like ginkgo biloba and St. John's wort. Hariyanto TI, Kwenandar F, Japar KV, Damay V, Kurniawan A. "This is the most concerning, because this wave of symptoms just continues to get gradually worse, peaking at around four months, and then just keeps going," says Wei. Patient-led research could transform medical research across diseases. 2020 Sep 17;17(9):e1003293. Measuring the impact of COVID-19 on the quality of life of the survivors, partners and family members: a cross-sectional international online survey. "I struggled to think clearly, and I had a moment in September where I realised I couldn't remember much at all from the summer. [x], Eighteen months after hospitalization, many patients report feeling fully recovered, yet are still affected they are sicker than they feel. A community for individuals suffering from the effects of COVID-19 longer than the estimated 4 weeks, also known as PACS, PASC, and Long Covid. They went to a doctor more often, had ongoing difficulty exercising, and experienced poor quality of life. A recent study showed that among these patients, performance in a six-minute walk test worsened, declining on average from 387 to 310 meters. In the US, we call them post-COVID "long haulers." Currently, the condition they are suffering from is known as "long COVID," although other names are being proposed. Cheema HA, Jafar U, Sohail A, et al. BMJ Open. More than half were never admitted to hospital for Covid-19. For example, a 2022 study by National Institutes of Health researchers compared 104 long-haulers with 85 short-term COVID patients and 120 healthy people and found no differences in measures of . The AMA Update covers a range of health care topics affecting the lives of physicians and patients. We needed a non-subjective way to determine if people were getting better immunologically, Patterson says. By studying survivors of the Sars coronavirus outbreaks of the early 2000s, and the West Africa Ebola crisis of the past decade, a handful of scientists think they know why it happens. I was able to eliminate more than 24 symptoms, Erlanson recalls. 2022;102:118-121. Heightman says that while 50% of UCLH's long Covid patients who were not admitted to hospital have improved over the course of a year to the point that they can manage their symptoms alone, the remaining half are still unwell. For all you Haulers out there .. comments sorted by Best Top New Controversial Q&A Add a Comment More posts from r/covidlonghaulers. Examples of the alternative medicines being tried range from quercetin a plant pigment found in green tea, onions and various berries to niacin, a form of vitamin B with antioxidant properties. [vii] PHOSP-COVID Collaborative Group. Explore how to write a medical CV, negotiate employment contracts and more. Mayo Clin Proc. 2022 Apr 22:S2213-2600(22)00127-8. doi: 10.1016/S2213-2600(22)00127-8. The SARS-CoV-2 virus enters the lungs and other organs via the angiotensin-converting enzyme 2 (ACE2) receptors. Practitioners need to be aware that any patient with one or more of a wide range of new symptoms could be suffering from long-haulers syndrome, even if they had only mild COVID-19. Biochem Pharmacol. Quercetin; Probiotic; Holistic medicine aims to improve health and wellness through the body, mind, and soul . 2021 May 28;12:669362. And in many cases, it is . Issue briefs summarize key health policy issues by providing concise and digestible content for both relevant stakeholders and those who may know little about the topic. 2021;103:25-32. doi:10.1016/j.ijid.2020.10.101, ShahR,AliFM,NixonSJ, et al. Clin Cosmet Investig Dermatol. More than a year since the pandemic began, scientists are starting to unravel what is causing long Covid and how they can treat it. In honor of Older Americans Month (May 1-31, 2023), the AMA celebrates senior physician members (ages 65 years and above). [xii] Davis HE, Assaf GS, McCorkell L, et al. Erlansons COVID-19 illness never progressed to the point that she had to be in the intensive care unit or on a ventilator, but she did have to be hospitalized three different times. including two annual Buyers Guides. This includes long Covid, but also a number of mysterious illnesses which have puzzled scientists for decades, such as chronic Lyme disease, and also ME/CFS, a condition which has long been speculated to have infectious origins although some scientists feel there could be a range of potential causes, and bears a number of similarities to long Covid. The second algorithm, involving a test known as the IncellKINE, examines the differences in cytokine responses between people with active cases of COVID-19 and long COVID patients. [xi], An international study showed that fatigue is the most common long-haulers syndrome, affecting 80% of all patients. [xxii] Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W, Yu F. A review of sleep disorders and melatonin. Learn more. [xxvi] Popescu MN, Berteanu M, Beiu C, et al. In addition to counseling on good sleep hygiene and encouraging rest and patience, I use this protocol to help my patients achieve better sleep: The supplements should be taken about an hour before the desired bedtime. J Transl Med. 2021 Nov 2;33(11):2174-2188.e5. Computerised tomography (CT) and Magnetic Resonance Imaging (MRI) scans swiftly reveal the extent of the damage, while drugs such as colchicine can be used to dampen down any lingering inflammation in the internal organs. But then came a breakthrough. 2020 Jul 13;24(1):422. doi: 10.1186/s13054-020-03120-0. PMID: 28460563. Brain fog can be debilitating, but there currently are no treatment options that are approved for the condition. Early research points to as many as 10 percent to 30 percent of people who contract COVID-19 will go onto be COVID long haulers. Some viruses are highly neurotrophic, meaning they can burrow into nerves, and hide out there, and there's evidence that Sars-CoV-2 is capable of this.". [x] FAIR Health White Paper, Patients Diagnosed with Post-COVID Conditions: An Analysis of Private Healthcare Claims Using the Official ICD-10 Diagnostic Code, May 18, 2022. Practitioners should also know that COVID-19 infection may create new metabolic conditions or unmask existing ones, such as insulin resistance. This is inspired by a similar reconditioning programme, which has been shown to be effective in treating a form of dysautonomia, known as POTS. Its like having the flu for 12 to 15 months, but without a fever.. ACT is not a complete panacea Kontorovich points out that some patients with particularly severe dysautonomia are often unable to complete the programme, because they feel too unwell but her early results show that it can benefit patients who are able to finish it. 0:00. Typically their lungs or heart have been damaged by either the acute viral infection, or the resulting cytokine storm the severe inflammatory response that can cause a patient's immune system to attack their own tissues. COVID-19 "long-haulers . The U.S. Centers for Disease Control (CDC) says people commonly report experiencing different combinations of the following symptoms: difficulty breathing or shortness of breath; tiredness or fatigue; symptoms that get worse after physical or mental activities (also known as post-exertional malaise); difficulty thinking or concentrating Published studies (see here and here ) and surveys conducted by patient groups indicate that 50% to 80% of patients continue to have bothersome symptoms three months after the . The effects also could lead to the development of new conditions, such as diabetes or a heart or nervous . Neurol Res. For me that was quite scary, as I normally have very vivid memories.". But more than 12 months later, 50 of them were still unwell, and John Patcai, a consultant at Toronto General Hospital, wanted to try and find out why. Risks and burdens of incident diabetes in long COVID: a cohort study. PMID: 34308300; PMCID: PMC8280690. stopmotionskeleton FYI: Stanford research staff have stopped masking in the middle of the long-Covid PAXLOVID study . Surges of inflammation in the bloodstream, either from an autoimmune reaction triggered by an infection, or the lingering presence of a virus, can cause these cells to pump out their own inflammatory molecules, which then disperse rapidly through the brain. Review CPT codes for COVID-19 vaccines and immunizations. From my experience with patients suffering from long-haulers syndrome, lifestyle, nutrition, supplements and laser all play a valuable role in managing symptoms and putting them on the path to improved health. However, it has not been evaluated in a systematic review until now. Here are a few examples of long COVID symptoms: Fatigue. Far from being unique to Sars-CoV-2 the virus that causes Covid-19 some scientists believe almost all infectious outbreaks leave behind a proportion of patients who remain chronically unwell with symptom patterns similar to long Covid. Here's where you'll find accurate, up-to-date information from the American Medical Association on the COVID-19 long hauler phenomenon. Patients generally had poorer health two years later and still experienced pain, fatigue, problems with sleeping and mental health issues. In healthy individuals, microglia play a key role in keeping the brain's neurons functioning normally, but they are vulnerable to disruption. It's a difficult task, because symptoms affect every system of the body, and also because cases can vary widely. Erlanson learned about two novel algorithms developed by IncellDx and COVID Long Haulers that examine changes to the immune system after a COVID infection and can predict the severity of long COVID. Over-the-counter antihistamines, typically taken for allergies, may help relieve the debilitating symptoms of long COVID in some people, a new case report suggests. Get Chiropractic Economics magazine There are no proven treatments for long Covid. "They felt weak, extremely fatigued, had aches and pains all over their body, and they were completely unable to work. Last month, Beth Israel Deaconess Medical Center . Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years experience in consumer-oriented health and wellness content. The neurological sequelae of long COVID poses a conundrum for physicians. You can joint by filling out a. Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menndez C, Moraleda C, Rogers L, Daniels K, Green P. Cochrane Database Syst Rev. 2021 Nov 1;4(11):e2134803. He is on the advisory board for Functional Medicine University and is a seasoned health and wellness expert on the speaking circuits and in the media. Full coverage of the Covid pandemic Geng and her colleagues at Stanford Medicine have embarked on the first clinical trial to test whether. fill out our form to request your FREE PMID: 34599884; PMCID: PMC8443335. Metabolic features of the cell danger response. [xxviii] Reiterer M, Rajan M, Gmez-Banoy N, et al. Apply for a leadership position by submitting the required documentation by the deadline. [xx], For patients experiencing insomnia related to anxiety and depression, I recommend the addition of Baikal skullcap (Scutellaria baicalensis), also known as Chinese skullcap. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Some surveys of patients have identified up to 98 different symptoms, while an international study published in July 2021 reported more than200 symptoms across 10 organ systems including the cardiovascular system, the nervous system, the brain and the respiratory system. Coughing. Agarwal A, Rochwerg B, Lamontagne F, et al. There's a huge amount of studies, which have been neglected by the mainstream medical community, showing how infectious organisms can persist in tissue, and contribute to disease processes. While ME/CFS is often regarded as an illness where sufferers rarely get better, Kaufman has an unusually high success rate, declaring that 15-20% of his patients have made a full recovery, although this claim is purely anecdotal. Patterson BK, Seethamraju H, Dhody K, et al. Experts say adequate sleep and exercise are probably the best things someone with long-term COVID-19 symptoms can do. With COVID long-hauler patients relatively new to the medical profession, there has been no decisive protocol for treating them. [xxv] Starace M, Iorizzo M, Sechi A, et al. Mitochondrion. [xxviii] A May 2022 study found that the risk of diabetes one year after acute COVID-19 infection increases by 40%. The healthcare system is taxed right now. 2021 Aug;38:101019. doi: 10.1016/j.eclinm.2021.101019. government site. Phytother Res. The .gov means its official. doi: 10.1093/infdis/jiac136. Some scientists perceive Covid-19 as an endothelial disease, where the inflammation generated against the virus ends up damaging the vascular endothelium, a fragile layer which acts as an interface between the blood and the body's tissues. Under normal conditions, about 100 hairs a day are usually shed. FOIA BMJ. Headaches. "I believe these viral fragments were interfering with how their brains were functioning, which would explain the poor sleep quality and other issues.". Since every person with the syndrome is unique, patients need a carefully designed but flexible long haul COVID treatment protocol tailored to their particular symptoms and needs. Finding effective treatments may require multiple approaches. Because ongoing inflammation can lower the threshold for tolerating some foods and toxins, patients should also be evaluated for food sensitivities and environmental toxins overload. For the majority of these patients, she hoped the road to full recovery would be swift. doi: 10.1016/j.jaad.2021.09.072. Thus far, the findings are mixed, but it may be useful in combination with other treatments in people that do get COVID-19, especially for those with severe illness. . I dont want them to have a single day where they have to suffer without an answer.. With expert resources and tireless advocacy, the AMA is your powerful ally against COVID-19. After the acute illness was over, nearly 25% of these patients had ongoing respiratory symptoms, chiefly shortness of breath and cough; 17% had fatigue, brain fog, and exhaustion that got worse with physical or mental activity. An international study showed that fatigue is the most common long-hauler's syndrome, affecting 80% of all patients. Early-onset effluvium secondary to COVID-19: Clinical and histologic characterization. doi: 10.1002/14651858.CD014217. Preventing COVID-19 infection by receiving the vaccine is key to avoiding long COVID. "[COVID deaths] are not pleasant deaths. Difficulty thinking or concentrating ("brain fog"), Fast-beating or pounding heart (also known as heart palpitations), Difficulty breathing or shortness of breath, Symptoms that get worse after physical or mental activities, Body Politicruns an online COVID-19 support group for people who tested positive for COVID-19, are experiencing symptoms, and are recovering from the illness. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. 2022 May 11:S2213-2600(22)00126-6. doi: 10.1016/S2213-2600(22)00126-6. According to Heightman, the peak age tends to be between 35 and 49, and they report a mysterious range of symptoms. 1 Symptoms vary significantly from person to person, and may include: 1 Tiredness or fatigue The general scientific consensus is that around one in 10 Covid-19 patients will still have symptoms 12 weeks later. The debilitating fatigue reported by many long-hauler patients may be related to virus-triggered damage to the mitochondria. PMID: 35325624; PMCID: PMC8937253. ", While Covid-19 is primarily thought of as a respiratory disease, the virus is capable of infecting many different tissues around the body (Credit: Naveen Sharma/Getty Images). Epub 2022 Jan 12. Curcumin for the treatment of COVID-19 patients: A meta-analysis of randomized controlled trials. Rather than subsiding, these symptoms continued to persist for weeks and even months after the virus had supposedly left their bodies. Quercetin is an acidic compound and shows metabolic interaction with some antivirals, antibiotics, and anti-inflammatory agents. Keywords: [xxix] All post-infection patients, particularly those with long-hauler syndrome, should be assessed for metabolic syndrome, prediabetes and diabetes. The caveat is that they are going to have some level of effects from being debilitated or sedentary for months on end, Patterson says. We used to be active members of the community. Efficacy and safety of molnupiravir for COVID-19 patients. [ii] Munipalli B, Seim L, Dawson NL, et al. 2022 Apr 22;15:735-743. doi: 10.2147/CCID.S359052. Review the list of candidates to serve on the AMA Board of Trustees and councils. Treatment for long COVID: supplementation, oxygenation, and suggested treatment modalities, Vitamin D in higher doses safe, even beneficial for some, Addressing Long COVID: $386 billion cost, 7% of U.S. adults suffering symptoms, Now glutathione a weapon for COVID recovery; new study shows reduction in oxidative stress, Cannabinoids protect against COVID; market predictions after new research revealed, How to reset and kickstart your immune system for patients, Standard Process welcomes new National Sales Director, NCMIC Foundation Recognizes 2023 McAndrews Award Winners, Cleveland University-Kansas City Launches New Continuing Education Website, NMN (nicotinamide mononucleotide), a precursor to NAD+: 200 mg/day, Hydrolyzed bovine collagen, Type 1 and Type 3: 250 mg, Amino acid blend: Glycine 300 mg, L-proline 250 mg, L-lysine HCL 250 mg, NAC 250 mg and L-methionine 50 mg. A recent study using U.S. health insurance records suggests that over 75% of people with long-haulers syndrome were never hospitalized for COVID. A month after the initial infection, a third wave of symptoms appears, including skin rashes, muscle pain, new allergies, and brain fog. Since 2013, Georgios Pollakis, a microbiologist at the University of Liverpool, has been working with hospitals across West Africa, monitoring reported cases of long Ebola, where survivors report pain, fatigue and a range of neurological symptoms including headaches and dizziness. Before Heightman says that two thirds of the UCLH clinic's long Covid patients admitted to hospital are now recovering well, while the remaining third have seen improvements in their scans after six months. It is also available in supplement form. Learn more about cardiovascular risks from long COVID-19, measles outbreaks and more. "We thought it would be like flu, it would all just go away, and be fine.". However, it has not been evaluated in a systematic review until now. Unauthorized use of these marks is strictly prohibited. The switch in cellular energy production favoring immune defense leaves little energy for other functions and leads to persistent fatigue.[xv]. Int J Infect Dis. Remdesivir for the treatment of COVID-19. Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project). A frequently published author in peer-reviewed journals and other mainstream publications, he is a thought leader in his field and practice. Amy Proal, a microbiologist who runs the PolyBio Research Foundation, which studies the causes of chronic inflammatory diseases, believes that small amounts of pathogens that linger beyond the reach of the immune system in remote pockets of the body, known as reservoirs or anatomical sanctuaries, are at least partially responsible for a whole range of post-infectious syndromes. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Ordinary people facing a death-defying problem . MSOP Outreach Leaders: Find all of the information you need for the year, including the leader guide, action plan checklist and more. [iii] cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-conditions.html. Post-acute sequelae of COVID-19: A metabolic perspective. Clinical use of CCR5 inhibitors in HIV and beyond. "My own cycle disappeared for three months," says Hannah Wei, part of the PLRC leadership team, who herself suffered from long Covid over the past year. Global reports show that a third of people who had COVID-19 experience lingering symptoms or new chronic health problemssome as long as a year after their initial infection. Some researchers have speculated that Covid-19 could be triggering the reactivation of viruses that have lain dormant in the body for years or even decades, leading to the development of chronic symptoms. Read our, New Criteria Helps Predict Which COVID-19 Patients Experience Cytokine Storm, First-of-Its-Kind Program Explores Most Common Long COVID Symptoms, A Hand-Held Device Is Helping COVID-19 Patients Breathe Again, Study: Exercise Improves Long COVID Fatigue, Have Long COVID and Can't Work?

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